The Excel Format of the Carcinogenic Potency Database

The Excel format is derived from the Carcinogenic Potency Database (CPDB) of Gold et al. that has been published in several earlier papers. This Excel format includes the same information as the plot version, and therefore the methods and guide to the plot provide details on what is summarized here. The CPDB is a single standardized resource of the results of 45 years of chronic, long-term carcinogenesis bioassays. The experiments vary widely in design, histopathological examination and nomenclature, and in the published authors’ choices of what information to publish in their papers. Data are included from 6153 experiments reported in the general literature and in the in Technical Reports of the National Cancer Institute/National Toxicology Program (NCI/NTP). Information is given in the CPDB on strain, sex, route of compound administration, target organ, histopathology, author’s opinion about carcinogenicity, and reference to the published paper, as well as quantitative data on statistical significance, tumor incidence, dose-response curve shape, length of experiment, duration of dosing, and dose-rate. The files on this Web site for the Excel format include (A) documentation of methods, field descriptions, and linking instructions; (B) Excel files; and (C) ancillary files of appendices.